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SUBS-014A
DABCYL-TNF-a-EDANS (-4 to +6), human
DABCYL-Leu-Ala-Gln-Ala-Val-Arg-Ser-Ser-Ser-Arg-EDANS
DABCYL-Leu-Ala-Gln-Ala-Val-Arg-Ser-Ser-Ser-Arg-EDANS
Size：0.5mg
P1(RMB)：460
MW：1573.8
One letter sequence：Dabcyl-LAQAVRSSSR-Edans
Molecular Formula： C70H104N22O18S1
Description：TACE FRET substrate I that is derived from the cleavage sequence of pro-TNFa recognized by the TNFa-cleaving enzyme (TACE). TNFa is presumably shed from cell membranes by TNFa-cleaving enzyme (TACE). Incubation of the TACE substrate with recombinant human TACE gives a specific cleavage to restore the quenched fluorescence. The substrate is widely used to screen inhibitors of TNF-convertase.
Literature Reference：A.J. H.Gearing et al., Nature , 370, 555 (1994) K.M. Mohler et al., Nature , 370, 218 (1994) Becker BF, et al.Biol Chem 383, 1821-6 (2002) Mohler KM, et al., Nature 370, 218-20. (1994)
Cas：
P1(RMB)：460
MW：1573.8
One letter sequence：Dabcyl-LAQAVRSSSR-Edans
Molecular Formula： C70H104N22O18S1
Description：TACE FRET substrate I that is derived from the cleavage sequence of pro-TNFa recognized by the TNFa-cleaving enzyme (TACE). TNFa is presumably shed from cell membranes by TNFa-cleaving enzyme (TACE). Incubation of the TACE substrate with recombinant human TACE gives a specific cleavage to restore the quenched fluorescence. The substrate is widely used to screen inhibitors of TNF-convertase.
Literature Reference：A.J. H.Gearing et al., Nature , 370, 555 (1994) K.M. Mohler et al., Nature , 370, 218 (1994) Becker BF, et al.Biol Chem 383, 1821-6 (2002) Mohler KM, et al., Nature 370, 218-20. (1994)
Cas：
